First Strike Rune League of Legends 2026
Attacks or abilities against an enemy champion within 0.25s of entering champion combat grants 10 (+4% damage dealt) gold and First Strike for 3 seconds, causing you to deal 7% extra damage against champions, and granting 100% (70% for ranged champions) of bonus damage dealt as gold.
Cooldown: 25 - 15s
Other runes
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Conditioning
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Dark Harvest
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Jack of All Trades
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Domination
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Ghost Poro
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Grisly Mementos
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Triumph
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Absorb Life
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Legend: Bloodline
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Nimbus Cloak
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Glacial Augment
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Coup de Grace
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Axiom Acanist
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Press the Attack
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Overgrowth
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Relentless Hunter
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Bone Plating
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Fleet Footwork
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Sorcery
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Sixth Sense
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Overheal
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Eyeball Collection
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Resolve
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Biscuit Delivery
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Grasp of the Undying
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Manaflow Band
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Triple Tonic
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Unsealed Spellbook
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Second Wind
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Nullifying Orb
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Transcendence
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Cosmic Insight
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Hail of Blades
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Legend: Alacrity
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Ravenous Hunter
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Press the Attack
